Linked Life Data

21297273

Source:http://linkedlifedata.com/resource/pubmed/id/21297273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-5-19
pubmed:abstractText
Few studies have investigated the apolipoprotein E (APOE) ?4 allele status of dementia patients with severe white matter hyperintensities (WMH). In this study, we aimed to characterize the APOE epsivlon genotypes and clinical features of dementia patients with severe WMH. Four hundred and thirty nine patients with dementia and 152 subjects with normal cognition (NC) were recruited from multiple centers in Korea, known as the Clinical Research Center for Dementia of South Korea (CREDOS), since November 2005. The WMH were rated using the scale that had been developed by the CREDOS study. Dementia patients with minimal WMH were considered to have Alzheimer's disease (AD) without WMH (AD-WMH: 325), and those with severe WMH were considered to have Subcortical Ischemic Vascular Dementia (SIVD: 50) or AD with severe WMH (AD+WMH: 64). Comparisons of APOE ?4 allelic prevalence were performed using chi-square analysis. The APOE ?4 allele was more prevalent in those with AD than in those with SIVD and NC (p < 0.001). It was not more prevalent in those with SIVD than in those with NC (p = 0.169). APOE ?4 allele status in AD+WMH did not differ from that in AD-WMH (p = 0.625). The APOE ?4 allele was more prevalent in those with AD than in those with SIVD. APOE ?4 may not be associated with SIVD although it is one of the vascular risk factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1875-8908
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
519-24
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
APOE ?4 allele status in korean dementia patients with severe white matter hyperintensities.
pubmed:affiliation
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't