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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-4
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pubmed:abstractText |
Miltipolone (1) was discovered as a good and broad-spectrum inhibitor against the growth of cancer cells from "Danshen" based on the activity-driven screening of TCMs. The structural features make 1 easily tautomerize between different forms and 1 is linked and stabilized by intermolecular O-H?O hydrogen bonds in the crystal structure. The interaction of 1 in ddH(2)O solution with Co(2+), Mn(2+), Zn(2+), Fe(2+) or Fe(3+) changed UV absorption values; the chelation of 1 with Fe(2+) or Fe(3+) also altered the characteristic UV absorption peaks. However, only did Fe(2+) reverse 1's inhibition against the growth of cancer cells; therefore, we concluded that 1 possibly acts as a Fe(2+) chelator to conduct its inhibitory activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1768-3254
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1117-21
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pubmed:meshHeading |
pubmed-meshheading:21296467-Antineoplastic Agents,
pubmed-meshheading:21296467-Cell Line, Tumor,
pubmed-meshheading:21296467-Cell Proliferation,
pubmed-meshheading:21296467-Crystallography, X-Ray,
pubmed-meshheading:21296467-Diterpenes,
pubmed-meshheading:21296467-Humans,
pubmed-meshheading:21296467-Iron,
pubmed-meshheading:21296467-Iron Chelating Agents,
pubmed-meshheading:21296467-Isomerism,
pubmed-meshheading:21296467-Models, Molecular,
pubmed-meshheading:21296467-Molecular Conformation,
pubmed-meshheading:21296467-Tropolone,
pubmed-meshheading:21296467-Water
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pubmed:year |
2011
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pubmed:articleTitle |
Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells.
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pubmed:affiliation |
Department of Applied Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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