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21295474
Source:
http://linkedlifedata.com/resource/pubmed/id/21295474
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0205314
,
umls-concept:C0456387
,
umls-concept:C0679622
,
umls-concept:C1999216
pubmed:issue
5
pubmed:dateCreated
2011-2-21
pubmed:abstractText
3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Aniline Compounds
,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds, 2-Ring
,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Macrophage...
,
http://linkedlifedata.com/resource/pubmed/chemical/aniline
,
http://linkedlifedata.com/resource/pubmed/chemical/cinnoline
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1464-3405
pubmed:author
pubmed-author:DakinLes ALA
,
pubmed-author:Del ValleDavid JDJ
,
pubmed-author:DieboldR BruceRB
,
pubmed-author:DrewLisaL
,
pubmed-author:GeroThomas WTW
,
pubmed-author:OgoeClaude ACA
,
pubmed-author:OmerCharles ACA
,
pubmed-author:RepikGalinaG
,
pubmed-author:ScottDavid ADA
,
pubmed-author:ThakurKumarK
,
pubmed-author:YeQingQ
,
pubmed-author:ZhengXiaolanX
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1382-4
pubmed:meshHeading
pubmed-meshheading:21295474-Amides
,
pubmed-meshheading:21295474-Aniline Compounds
,
pubmed-meshheading:21295474-Animals
,
pubmed-meshheading:21295474-Dogs
,
pubmed-meshheading:21295474-Heterocyclic Compounds, 2-Ring
,
pubmed-meshheading:21295474-Mice
,
pubmed-meshheading:21295474-Molecular Structure
,
pubmed-meshheading:21295474-Protein Kinase Inhibitors
,
pubmed-meshheading:21295474-Rats
,
pubmed-meshheading:21295474-Receptor, Macrophage Colony-Stimulating Factor
,
pubmed-meshheading:21295474-Structure-Activity Relationship
pubmed:year
2011
pubmed:articleTitle
3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.
pubmed:affiliation
Cancer Research, AstraZeneca R&D Boston, Waltham, MA 02451, USA. david.scott@astrazeneca.com
pubmed:publicationType
Journal Article