Linked Life Data

21295305

Source:http://linkedlifedata.com/resource/pubmed/id/21295305

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-4-18
pubmed:abstractText
Tissue mechanical parameters have been shown to be highly sensitive to disease by elastography. Magnetic resonance elastography (MRE) in the human body relies on the low-dynamic range of tissue mechanics <100 Hz. In contrast, MRE suited for investigations of mice or small tissue samples requires vibration frequencies 10-20 times higher than those used in human MRE. The dispersion of the complex shear modulus (G(?)) prevents direct comparison of elastography data at different frequency bands and, consequently, frequency-independent viscoelastic models that fit to G(*) over a wide dynamic range have to be employed. This study presents data of G(*) of samples of agarose gel, liver, brain, and muscle measured by high-resolution MRE in a 7T-animal scanner at 200-800 Hz vibration frequency. Material constants ? and ? according to the springpot model and related to shear elasticity and slope of the G(*)-dispersion were determined. Both ? and ? of calf brain and bovine liver were found to be similar, while a sample of fibrotic human liver (METAVIR score of 3) displayed about fifteen times higher shear elasticity, similar to ? of bovine muscle measured in muscle fiber direction. ? was the highest in fibrotic liver, followed by normal brain and liver, while muscle had the lowest ?-values of all biological samples investigated in this study. As expected, the least G(*)-dispersion was seen in soft gel. The proposed technique of wide-range dynamic MRE can provide baseline data for both human MRE and high-dynamic MRE for better understanding tissue mechanics of different tissue structures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-2380
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
29
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1380-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Wide-range dynamic magnetic resonance elastography.
pubmed:affiliation
Department of Medical Informatics, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't