rdf:type |
|
lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0009015,
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0085424,
umls-concept:C0086418,
umls-concept:C0143630,
umls-concept:C0185117,
umls-concept:C1334043,
umls-concept:C2911684
|
pubmed:issue |
1
|
pubmed:dateCreated |
1991-10-22
|
pubmed:abstractText |
A cDNA encoding the human homolog of mouse T-cell and mast cell growth factor P40 was derived from peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin and phorbol myristate acetate. Sequence analysis of the cDNA predicted a precursor protein of 144 amino acids including a signal peptide of 18 residues, a structure identical with that of mouse P40. The homology between the mouse and human proteins is 55% with a perfect conservation of the 10 cysteine residues present in the mature polypeptide. Expression of the cDNA for human P40 in a baculovirus vector yielded a protein capable of enhancing in vitro survival of human T cell lines.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1043-4666
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
9-12
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2129501-Amino Acid Sequence,
pubmed-meshheading:2129501-Base Sequence,
pubmed-meshheading:2129501-Blotting, Northern,
pubmed-meshheading:2129501-Cloning, Molecular,
pubmed-meshheading:2129501-DNA,
pubmed-meshheading:2129501-Gene Expression,
pubmed-meshheading:2129501-Growth Substances,
pubmed-meshheading:2129501-Humans,
pubmed-meshheading:2129501-Interleukin-9,
pubmed-meshheading:2129501-Interleukins,
pubmed-meshheading:2129501-Molecular Sequence Data,
pubmed-meshheading:2129501-RNA, Messenger
|
pubmed:year |
1990
|
pubmed:articleTitle |
Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40.
|
pubmed:affiliation |
Unit of Experimental Medicine, Université Catholique de Louvain, Belgium.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|