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pubmed-article:21293012pubmed:abstractTextThe sodium-calcium exchanger-1 (NCX1) represents a key mediator for maintaining [Na(+)](i) and [Ca(2+)](i) homeostasis. Although changes in NCX1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still unknown. Thus far, however, there is evidence that hypoxia-inducible factor-1 (HIF-1) is a nuclear factor required for transcriptional activation of several genes implicated in stroke. The main objective of this study was to investigate whether NCX1 gene might be a novel target of HIF-1 in the brain.lld:pubmed
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pubmed-article:21293012pubmed:articleTitleNCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.lld:pubmed
pubmed-article:21293012pubmed:affiliationDivision of Pharmacology, Department of Neuroscience, School of Medicine, "Federico II" University of Naples, Via S. Pansini 5, 80131 Naples, Italy.lld:pubmed
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