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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-21
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pubmed:abstractText |
The sodium-calcium exchanger-1 (NCX1) represents a key mediator for maintaining [Na(+)](i) and [Ca(2+)](i) homeostasis. Although changes in NCX1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still unknown. Thus far, however, there is evidence that hypoxia-inducible factor-1 (HIF-1) is a nuclear factor required for transcriptional activation of several genes implicated in stroke. The main objective of this study was to investigate whether NCX1 gene might be a novel target of HIF-1 in the brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4628
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pubmed:author |
pubmed-author:AnnunziatoLucioL,
pubmed-author:BosciaFrancescaF,
pubmed-author:Del PreteAnnalisaA,
pubmed-author:Di RenzoGianfrancoG,
pubmed-author:EspositoElgaE,
pubmed-author:MatroneCarmelaC,
pubmed-author:PignataroGiuseppeG,
pubmed-author:ScorzielloAntonellaA,
pubmed-author:SirabellaRossanaR,
pubmed-author:SisalliMaria JosèMJ,
pubmed-author:ValsecchiValeriaV,
pubmed-author:ZambranoNicolaN
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
754-63
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pubmed:meshHeading |
pubmed-meshheading:21293012-Animals,
pubmed-meshheading:21293012-Brain,
pubmed-meshheading:21293012-Cell Line, Tumor,
pubmed-meshheading:21293012-Cells, Cultured,
pubmed-meshheading:21293012-Gene Targeting,
pubmed-meshheading:21293012-Humans,
pubmed-meshheading:21293012-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:21293012-Ischemic Attack, Transient,
pubmed-meshheading:21293012-Ischemic Preconditioning,
pubmed-meshheading:21293012-Male,
pubmed-meshheading:21293012-Rats,
pubmed-meshheading:21293012-Rats, Sprague-Dawley,
pubmed-meshheading:21293012-Rats, Wistar,
pubmed-meshheading:21293012-Sodium-Calcium Exchanger
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pubmed:year |
2011
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pubmed:articleTitle |
NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.
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pubmed:affiliation |
Division of Pharmacology, Department of Neuroscience, School of Medicine, "Federico II" University of Naples, Via S. Pansini 5, 80131 Naples, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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