Source:http://linkedlifedata.com/resource/pubmed/id/21292026
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-4-13
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| pubmed:abstractText |
There are conflicting reports concerning the association of Toxoplasma gondii infection and schizophrenia in humans. Therefore, we determined such association in a Mexican population of Mestizo ethnicity. Through a case-control study design, 50 schizophrenic patients and 150 control subjects matched by gender, age, residence place, and ethnicity were examined with enzyme-linked immunoassays for the presence and levels of T. gondii IgG antibodies and for the presence of T. gondii IgM antibodies. Schizophrenic patients attended a public psychiatric hospital in Durango City, Mexico, and the control group consisted of individuals of the general population of the same city. Socio-demographic, clinical and behavioral characteristics from the study subjects were also obtained. Both the seroprevalence and the level of T.gondii IgG antibodies were higher in schizophrenic patients (10/50; 20%) than in control subjects (8/150; 5.3%) (OR=4.44; 95% CI: 1.49-13.37; P=0.003). The IgG T. gondii levels higher than 150 IU/ml were more frequently observed in patients than in controls (10% versus 2%, respectively; P=0.02). One (50%) of the two patients with recently diagnosed schizophrenia and none of the controls had T. gondii IgM antibodies (P=0.01). T. gondii seropositivity was significantly higher in patients with a history of cleaning cat excrement (P=0.005), and suffering from simple schizophrenia (ICD-10 classification: F20.6) (P=0.03) than patients without these characteristics. Toxoplasma seroprevalence was also significantly higher in patients with simple schizophrenia (F20.6) than in those with paranoid schizophrenia (F20.0) (P=0.02). This study provides elements to clarify the controversial information on the association of T. gondii infection and schizophrenia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1873-0329
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| pubmed:author | |
| pubmed:copyrightInfo |
Published by Elsevier Ireland Ltd.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
60
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
151-5
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| pubmed:meshHeading |
pubmed-meshheading:21292026-Adolescent,
pubmed-meshheading:21292026-Adult,
pubmed-meshheading:21292026-Aged,
pubmed-meshheading:21292026-Animals,
pubmed-meshheading:21292026-Antibodies, Protozoan,
pubmed-meshheading:21292026-Case-Control Studies,
pubmed-meshheading:21292026-Cats,
pubmed-meshheading:21292026-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21292026-Female,
pubmed-meshheading:21292026-Humans,
pubmed-meshheading:21292026-Immunoglobulin G,
pubmed-meshheading:21292026-Immunoglobulin M,
pubmed-meshheading:21292026-Logistic Models,
pubmed-meshheading:21292026-Male,
pubmed-meshheading:21292026-Mexico,
pubmed-meshheading:21292026-Middle Aged,
pubmed-meshheading:21292026-Questionnaires,
pubmed-meshheading:21292026-Schizophrenia,
pubmed-meshheading:21292026-Seroepidemiologic Studies,
pubmed-meshheading:21292026-Socioeconomic Factors,
pubmed-meshheading:21292026-Toxoplasma,
pubmed-meshheading:21292026-Toxoplasmosis,
pubmed-meshheading:21292026-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Toxoplasma gondii infection and schizophrenia: a case control study in a low Toxoplasma seroprevalence Mexican population.
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| pubmed:affiliation |
Faculty of Medicine, Juárez University of Durango State, Avenida Universidad S/N esquina Fanny Anitua, 34000 Durango, Dgo, Mexico. alvaradocosme@yahoo.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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