Linked Life Data

21291971

Source:http://linkedlifedata.com/resource/pubmed/id/21291971

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2011-4-1
pubmed:abstractText
Baicalin-polyvinylpyrrolidone (PVP) coprecipitate was prepared by the solvent method of solid dispersion technology to improve the dissolution rate of baicalin. The coprecipitate was characterized using differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), infrared spectrometry (IR) and dissolution testing. Furthermore, AFM·IPC-208B high-resolution atomic force microscopy (AFM) was utilized to characterize the molecular morphology of baicalin within its carrier and the interaction between baicalin and its carrier. The results of DSC and XRD indicated that baicalin resided in PVP polymers in an amorphous or molecular phase, dissolution test results demonstrated that the dissolution rate of the coprecipitate was 21.4 times that of the active pharmaceutical ingredient (API). The results of IR indicated the possibility of the formation of intermolecular hydrogen bonds. The AFM·IPC-208B findings revealed that baicalin was dispersed in PVP polymers with a molecular size of 2 nm and either wrapped or surrounded by approximately 0.4 nm of a five-membered ring of PVP arranged along the carbon chain sequentially. An intermolecular hydrogen bond was formed between the 4-OH of the glucuronide of baicalin and the O of the carbonyl group from PVP in addition to the formation of intramolecular hydrogen bonds within baicalin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-3476
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
408
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Preparation and characterization of baicalin-poly -vinylpyrrolidone coprecipitate.
pubmed:affiliation
Department of Radiation, Collage of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't