Source:http://linkedlifedata.com/resource/pubmed/id/21291323
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2011-6-2
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pubmed:databankReference | |
pubmed:abstractText |
In HIV-infected individuals on antiretroviral treatment with viral suppression, structured treatment interruptions are designed to allow exposure to endogenous HIV antigens and to thereby boost HIV-specific immunity. AIDS Clinical Trials Group A5132 was an exploratory 2-arm randomized trial that evaluated two 4-week treatment interruptions in combination with 2 strategies for administering interleukin-2 (IL-2): 2.0 million international units of IL-2 subcutaneously daily during the final 2 weeks of treatment interruption and the first week of treatment reinitiation (arm A), or 4.5 million international units of IL-2 subcutaneously twice a day during the first 5 days of treatment reinitiation (arm B). Twenty-one subjects with HIV-1 RNA <50 copies/mL and CD4+ T cell counts ?300 (median 615) cells/mm(3) were randomized. The primary endpoint was the viral setpoint measured 11-12 weeks after a third treatment interruption (observed for 7 Arm A and 9 Arm B). The median HIV-1 RNA setpoints were 4.3 and 4.5 log(10) copies/mL for Arm A and Arm B, respectively; there was no evidence of a difference between arms (P = 0.50, rank-sum test, worst rank for unobserved viral setpoint). The current study, the first to evaluate IL-2 during repeated short-term treatment interruptions, revealed no evidence for augmentation of HIV immunity. Viral setpoints were similar to historical controls, emphasizing the need for new strategies to enhance HIV-specific immunity.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI 32782,
http://linkedlifedata.com/resource/pubmed/grant/AI 38855,
http://linkedlifedata.com/resource/pubmed/grant/AI 38858,
http://linkedlifedata.com/resource/pubmed/grant/AI 68634,
http://linkedlifedata.com/resource/pubmed/grant/AI 68636,
http://linkedlifedata.com/resource/pubmed/grant/AI 69477,
http://linkedlifedata.com/resource/pubmed/grant/AI 69556
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1557-7465
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-3
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pubmed:meshHeading |
pubmed-meshheading:21291323-Adjuvants, Immunologic,
pubmed-meshheading:21291323-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:21291323-Clinical Protocols,
pubmed-meshheading:21291323-Female,
pubmed-meshheading:21291323-Follow-Up Studies,
pubmed-meshheading:21291323-HIV,
pubmed-meshheading:21291323-HIV Infections,
pubmed-meshheading:21291323-Humans,
pubmed-meshheading:21291323-Immunotherapy,
pubmed-meshheading:21291323-Interleukin-2,
pubmed-meshheading:21291323-Male,
pubmed-meshheading:21291323-Middle Aged,
pubmed-meshheading:21291323-RNA, Viral,
pubmed-meshheading:21291323-Virus Replication,
pubmed-meshheading:21291323-Withholding Treatment
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pubmed:year |
2011
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pubmed:articleTitle |
A randomized trial of interleukin-2 during withdrawal of antiretroviral treatment.
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pubmed:affiliation |
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA. rbosch@hsph.harvard.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, N.I.H., Extramural
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