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rdf:type |
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lifeskim:mentions |
umls-concept:C0000768,
umls-concept:C0169665,
umls-concept:C0205422,
umls-concept:C0262587,
umls-concept:C0544886,
umls-concept:C0679058,
umls-concept:C1332737,
umls-concept:C1519249,
umls-concept:C1547699,
umls-concept:C1705523,
umls-concept:C2700640
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-8
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pubmed:abstractText |
Typical nonfamilial (sporadic) parathyroid adenomas are common endocrine tumors for which no predisposing germline DNA variants and only a few clonally altered genes that drive parathyroid tumorigenesis have been identified. CDKN1B, encoding cyclin-dependent kinase inhibitor p27(kip1), has recently been implicated in a multiple endocrine tumor phenotype in rats and, rarely, in a human familial MEN1 (multiple endocrine neoplasia type 1)-like disorder.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1945-7197
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E701-6
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pubmed:meshHeading |
pubmed-meshheading:21289244-Adenoma,
pubmed-meshheading:21289244-Adult,
pubmed-meshheading:21289244-Aged,
pubmed-meshheading:21289244-Aged, 80 and over,
pubmed-meshheading:21289244-Case-Control Studies,
pubmed-meshheading:21289244-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:21289244-DNA Mutational Analysis,
pubmed-meshheading:21289244-Female,
pubmed-meshheading:21289244-Genetic Predisposition to Disease,
pubmed-meshheading:21289244-Germ-Line Mutation,
pubmed-meshheading:21289244-Humans,
pubmed-meshheading:21289244-Male,
pubmed-meshheading:21289244-Middle Aged,
pubmed-meshheading:21289244-Mutation,
pubmed-meshheading:21289244-Open Reading Frames,
pubmed-meshheading:21289244-Parathyroid Neoplasms
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pubmed:year |
2011
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pubmed:articleTitle |
Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas.
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pubmed:affiliation |
Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030-3101, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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