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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-3
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pubmed:abstractText |
Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans. Although recombinant human MBL (rhMBL) trials have focused on reconstitution therapy, safety studies have identified no barriers to its use at higher levels. Ebola viruses cause fatal hemorrhagic fevers for which no treatment exists and that are feared as potential biothreat agents. We found that mice whose rhMBL serum concentrations were increased ?7-fold above average human levels survived otherwise fatal Ebola virus infections and became immune to virus rechallenge. Because Ebola glycoproteins potentially model other glycosylated viruses, rhMBL may offer a novel broad-spectrum antiviral approach.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1537-6613
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pubmed:author |
pubmed-author:BrudnerMatthewM,
pubmed-author:EzekowitzR Alan BRA,
pubmed-author:KarpelMarshallM,
pubmed-author:LearCalliC,
pubmed-author:LongleyClifford BCB,
pubmed-author:MichelowIan CIC,
pubmed-author:OlingerGene GGG,
pubmed-author:PrugarLaura ILI,
pubmed-author:SchmidtEmmett VEV,
pubmed-author:ScullyCorinneC,
pubmed-author:SpearGregory TGT,
pubmed-author:TakahashiKazueK,
pubmed-author:YantoscaL MichaelLM,
pubmed-author:ZecZZ
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
203
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-9
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pubmed:dateRevised |
2011-4-6
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pubmed:meshHeading |
pubmed-meshheading:21288816-Animals,
pubmed-meshheading:21288816-Antiviral Agents,
pubmed-meshheading:21288816-Ebolavirus,
pubmed-meshheading:21288816-Hemorrhagic Fever, Ebola,
pubmed-meshheading:21288816-Humans,
pubmed-meshheading:21288816-Immunologic Factors,
pubmed-meshheading:21288816-Mannose-Binding Lectin,
pubmed-meshheading:21288816-Mice,
pubmed-meshheading:21288816-Mice, Knockout,
pubmed-meshheading:21288816-Recombinant Proteins,
pubmed-meshheading:21288816-Survival Analysis,
pubmed-meshheading:21288816-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
High-dose mannose-binding lectin therapy for Ebola virus infection.
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pubmed:affiliation |
Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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