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21284701
Source:
http://linkedlifedata.com/resource/pubmed/id/21284701
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Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0079411
,
umls-concept:C0079925
,
umls-concept:C0086418
,
umls-concept:C0183683
,
umls-concept:C0344211
,
umls-concept:C0936012
,
umls-concept:C1171411
,
umls-concept:C1317973
,
umls-concept:C1511726
,
umls-concept:C1521721
,
umls-concept:C1707689
,
umls-concept:C1709630
,
umls-concept:C1832051
,
umls-concept:C2603343
pubmed:issue
3
pubmed:dateCreated
2011-2-2
pubmed:abstractText
To predict the concentration and target inhibition profiles of the survivin inhibitor antisense oligonucleotide LY2181308 in humans.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/7503323
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Investigational
,
http://linkedlifedata.com/resource/pubmed/chemical/LY 2181308
,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides
,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense
,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1365-2125
pubmed:author
pubmed-author:AndréValérieV
,
pubmed-author:BurgessMichaelM
,
pubmed-author:CalliesSophieS
,
pubmed-author:FrancisPaulP
,
pubmed-author:LahnMichaelM
,
pubmed-author:PatelBharvinB
,
pubmed-author:WatersDavidD
pubmed:copyrightInfo
© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.
pubmed:issnType
Electronic
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
416-28
pubmed:meshHeading
pubmed-meshheading:21284701-Animals
,
pubmed-meshheading:21284701-Body Weight
,
pubmed-meshheading:21284701-Dose-Response Relationship, Drug
,
pubmed-meshheading:21284701-Drug Evaluation, Preclinical
,
pubmed-meshheading:21284701-Drugs, Investigational
,
pubmed-meshheading:21284701-Haplorhini
,
pubmed-meshheading:21284701-Humans
,
pubmed-meshheading:21284701-Mice
,
pubmed-meshheading:21284701-Models, Biological
,
pubmed-meshheading:21284701-Neoplasms
,
pubmed-meshheading:21284701-Oligonucleotides
,
pubmed-meshheading:21284701-Oligonucleotides, Antisense
,
pubmed-meshheading:21284701-RNA, Messenger
,
pubmed-meshheading:21284701-Research Design
pubmed:year
2011
pubmed:articleTitle
Integrated analysis of preclinical data to support the design of the first in man study of LY2181308, a second generation antisense oligonucleotide.
pubmed:affiliation
Eli Lilly and Company, 13 rue Pages, Suresnes, 92158 France Eli Lilly and Company, Erlwood Manor, Sunninghill Road, Windlesham, GU20 6PH, UK. Callies_sophie@lilly.com
pubmed:publicationType
Journal Article