Linked Life Data

21284400

Source:http://linkedlifedata.com/resource/pubmed/id/21284400

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-2-25
pubmed:abstractText
In this report, we disclose our findings regarding the remarkable effect of a low-level impurity found in the solvent used for a ruthenium-catalyzed direct arylation reaction. This discovery allowed for the development of a robust and high-yield arylation protocol that was demonstrated on a multikilogram scale using carboxylate as the cocatalyst. Finally, a practical, scalable, and chromatography-free synthesis of the biaryl core of Anacetrapib is described.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1520-6904
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1436-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Preparative scale synthesis of the biaryl core of anacetrapib via a ruthenium-catalyzed direct arylation reaction: unexpected effect of solvent impurity on the arylation reaction.
pubmed:affiliation
Department of Process Research, Merck Frosst Canada, Kirkland, Quebec, Canada. stephane_ouellet@merck.com
pubmed:publicationType
Journal Article