Linked Life Data

21282195

Source:http://linkedlifedata.com/resource/pubmed/id/21282195

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-2-1
pubmed:abstractText
In patients with falciparum malaria, plasma concentrations of cell-derived microparticles correlate with disease severity. Using flow cytometry, we quantified red blood cell-derived microparticles (RMPs) in patients with malaria and identified the source and the factors associated with production. RMP concentrations were increased in patients with Plasmodium falciparum (n = 29; median, 457 RMPs/?L [range, 13-4,342 RMPs/?L]), Plasmodium vivax (n = 5; median, 409 RMPs/?L [range, 281-503/?L]), and Plasmodium malariae (n = 2; median, 163 RMPs/?L [range, 127-200 RMPs/?L]) compared with those in healthy subjects (n = 11; median, 8 RMPs/?L [range, 3-166 RMPs/?L]; P = .01). RMP concentrations were highest in patients with severe falciparum malaria (P = .01). Parasitized red cells produced >10 times more RMPs than did unparasitized cells, but the overall majority of RMPs still derived from uninfected red blood cells (URBCs). In cultures, RMP production increased as the parasites matured. Hemin and parasite products induced RMP production in URBCs, which was inhibited by N-acetylcysteine, suggesting heme-mediated oxidative stress as a pathway for the generation of RMPs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1537-6613
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
203
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
700-6
pubmed:dateRevised
2011-6-21
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Circulating red cell-derived microparticles in human malaria.
pubmed:affiliation
Department of Clinical Microscopy, Faculty of Allied Health Science, Chulalongkorn University, Bangkok, Thailand.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't