Linked Life Data

21281539

Source:http://linkedlifedata.com/resource/pubmed/id/21281539

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pubmed-article:21281539pubmed:dateCreated2011-3-18lld:pubmed
pubmed-article:21281539pubmed:abstractTextIt is well known that c-Jun N-terminal kinase (JNK) plays pivotal roles in various mitotic events, but its function in mammalian oocyte meiosis remains unknown. In this study, we found that no specific JNK2 signal was detected in germinal vesicle stage. JNK2 was associated with the spindles especially the spindle poles and cytoplasmic microtubule organizing centers at prometaphase I, metaphase I, and metaphase II stages. JNK2 became diffusely distributed and associated with the midbody at telophase I stage. Injection of myc-tagged JNK2?1 mRNA into oocytes also revealed its localization on spindle poles. The association of JNK2 with spindle poles was further confirmed by colocalization with the centrosomal proteins, ?-tubulin and Plk1. Nocodazole treatment showed that JNK2 may interact with Plk1 to regulate the spindle assembly. Then we investigated the possible function of JNK2 by JNK2 antibody microinjection and JNK specific inhibitor SP600125 treatment. These two manipulations caused abnormal spindle formation and decreased the rate of first polar body (PB1) extrusion. In addition, inhibition of JNK2 resulted in impaired localization of Plk1. Taken together, our results suggest that JNK2 plays an important role in spindle assembly and PB1 extrusion during mouse oocyte meiotic maturation.lld:pubmed
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pubmed-article:21281539pubmed:authorpubmed-author:HuangXinXlld:pubmed
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pubmed-article:21281539pubmed:dateRevised2011-11-2lld:pubmed
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pubmed-article:21281539pubmed:year2011lld:pubmed
pubmed-article:21281539pubmed:articleTitleJNK2 participates in spindle assembly during mouse oocyte meiotic maturation.lld:pubmed
pubmed-article:21281539pubmed:affiliationOrgan Transplantation Institute, Xiamen University, Xiamen City, Fujian Province, China.lld:pubmed
pubmed-article:21281539pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21281539pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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