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rdf:type |
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lifeskim:mentions |
umls-concept:C0004153,
umls-concept:C0016390,
umls-concept:C0023779,
umls-concept:C0024141,
umls-concept:C0033414,
umls-concept:C0205314,
umls-concept:C0208973,
umls-concept:C0243144,
umls-concept:C0679622,
umls-concept:C1517892,
umls-concept:C1522492,
umls-concept:C1704666
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pubmed:issue |
2
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|
pubmed:dateCreated |
2011-1-31
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|
pubmed:abstractText |
An increased risk of premature atherosclerosis has been associated with systemic lupus erythematosus (SLE), and type I interferon (IFN) has been shown to play a pathogenic role in human SLE. The aim of this study was to determine whether IFN? is involved in the development of atherosclerosis in patients with SLE by promoting lipid uptake and macrophage-derived foam cell formation, which is a crucial step in early atherosclerosis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1529-0131
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 by the American College of Rheumatology.
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
492-502
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pubmed:meshHeading |
pubmed-meshheading:21280004-Atherosclerosis,
pubmed-meshheading:21280004-Cell Line, Tumor,
pubmed-meshheading:21280004-Female,
pubmed-meshheading:21280004-Foam Cells,
pubmed-meshheading:21280004-Gene Expression,
pubmed-meshheading:21280004-Humans,
pubmed-meshheading:21280004-Interferon-alpha,
pubmed-meshheading:21280004-Leukocytes, Mononuclear,
pubmed-meshheading:21280004-Lipid Metabolism,
pubmed-meshheading:21280004-Lupus Erythematosus, Systemic,
pubmed-meshheading:21280004-Male,
pubmed-meshheading:21280004-Phosphatidylinositol 3-Kinase,
pubmed-meshheading:21280004-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21280004-RNA, Messenger,
pubmed-meshheading:21280004-Scavenger Receptors, Class A,
pubmed-meshheading:21280004-Signal Transduction,
pubmed-meshheading:21280004-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Interferon-? priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon-? and atherosclerosis in lupus.
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pubmed:affiliation |
Shanghai Institute of Rheumatology, Renji Hospital, Molecular Rheumatology Laboratory of Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai JiaoTong University School of Medicine, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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