Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-31
pubmed:abstractText
Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial research focuses on the isolation of bioactive lead compound(s). The development of novel plant-derived natural products and their analogs for anticancer activity details efforts to synthesize new derivatives based on bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design - based modification. Also, the anticancer activity of certain natural products and their analogs can be enhanced by synthesizing new derivatives based on active pharmacophore models; drug resistance and solubility and metabolic limitations can be overcome by appropriate molecular modifications; and new biological properties or mechanisms of action can be added by combining other functional groups or molecules. Preclinical screening for in vitro human cell line panels and selected in vivo xenograft testing then identifies the most promising drug development targets.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-10420081, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-1431932, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-1453183, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-1512598, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-1651156, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-1758445, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-1955882, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-2167985, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-2236294, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-2380715, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-2550587, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-2848132, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-3030329, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-3290912, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-3669007, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-3783593, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-3841556, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-5165570, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-6391663, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-6508830, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-7320737, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-7328595, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-7561896, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-7788302, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-7922123, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-7932568, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-8164254, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-8295216, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-8395599, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-8691468, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-8691469, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-9083485, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-9216846, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-9313853, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-9313854, http://linkedlifedata.com/resource/pubmed/commentcorrection/21279166-9313855
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Mar
pubmed:issn
0253-7613
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-58
pubmed:dateRevised
2011-7-25
pubmed:year
2008
pubmed:articleTitle
A review on plant-derived natural products and their analogs with anti-tumor activity.
pubmed:affiliation
A.R College of Pharmacy affiliated to Sardar Patel University, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120, India.
pubmed:publicationType
Journal Article