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rdf:type |
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lifeskim:mentions |
umls-concept:C0021792,
umls-concept:C0025260,
umls-concept:C0043227,
umls-concept:C1413038,
umls-concept:C1428114,
umls-concept:C1514811,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1561577,
umls-concept:C1563350,
umls-concept:C1563351,
umls-concept:C1619636,
umls-concept:C1706462
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-24
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pubmed:abstractText |
Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-10491611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-11955958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-12195431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-12890769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-15661633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-15803162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-17122364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-17296559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-18063801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-18287499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-18599766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-18614669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-19204281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21278730-9952425
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1546-1726
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-9
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:21278730-Animals,
pubmed-meshheading:21278730-Behavior, Animal,
pubmed-meshheading:21278730-Hippocampus,
pubmed-meshheading:21278730-Interneurons,
pubmed-meshheading:21278730-Memory, Short-Term,
pubmed-meshheading:21278730-Metalloendopeptidases,
pubmed-meshheading:21278730-Mice,
pubmed-meshheading:21278730-Neuropsychological Tests,
pubmed-meshheading:21278730-Parvalbumins,
pubmed-meshheading:21278730-Recombinant Fusion Proteins,
pubmed-meshheading:21278730-Space Perception,
pubmed-meshheading:21278730-Tetanus Toxin,
pubmed-meshheading:21278730-Vesicle-Associated Membrane Protein 2,
pubmed-meshheading:21278730-gamma-Aminobutyric Acid
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pubmed:year |
2011
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pubmed:articleTitle |
Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory.
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pubmed:affiliation |
Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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