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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-4
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pubmed:abstractText |
The uptake carrier organic anion-transporting polypeptide 1B3 (OATP1B3, gene SLCO1B3) is involved in the hepatic clearance of xenobiotics including statins, taxanes, and mycophenolic acid. We thought to assess the SLCO1B3 coding region for yet unidentified polymorphisms and to analyze their functional relevance.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fluorobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters...,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/SLCO1B3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sincalide,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/atorvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/rosuvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1744-6880
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-14
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pubmed:dateRevised |
2011-8-10
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pubmed:meshHeading |
pubmed-meshheading:21278621-Amino Acid Sequence,
pubmed-meshheading:21278621-Amino Acid Substitution,
pubmed-meshheading:21278621-Fluorobenzenes,
pubmed-meshheading:21278621-Gene Expression,
pubmed-meshheading:21278621-HeLa Cells,
pubmed-meshheading:21278621-Heptanoic Acids,
pubmed-meshheading:21278621-Humans,
pubmed-meshheading:21278621-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:21278621-Liver,
pubmed-meshheading:21278621-Molecular Sequence Data,
pubmed-meshheading:21278621-Mutagenesis, Site-Directed,
pubmed-meshheading:21278621-Organic Anion Transporters, Sodium-Independent,
pubmed-meshheading:21278621-Polymorphism, Genetic,
pubmed-meshheading:21278621-Protein Conformation,
pubmed-meshheading:21278621-Pyrimidines,
pubmed-meshheading:21278621-Pyrroles,
pubmed-meshheading:21278621-Sincalide,
pubmed-meshheading:21278621-Structure-Activity Relationship,
pubmed-meshheading:21278621-Substrate Specificity,
pubmed-meshheading:21278621-Sulfonamides
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pubmed:year |
2011
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pubmed:articleTitle |
Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity.
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pubmed:affiliation |
Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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