Source:http://linkedlifedata.com/resource/pubmed/id/21277853
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2011-4-25
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pubmed:abstractText |
The nitric oxide-guanosine 3',5'-cyclic monophosphate (cGMP) signaling pathway has an important role in the control of smooth muscle tone. NO is produced by NO synthases and acts as a major inhibitory neurotransmitter in the gastrointestinal (GI) tract. The main target, NO-sensitive guanylyl cyclase (NO-GC), is stimulated by NO to produce the intracellular messenger cGMP. We investigated the role of NO-GC in nitrergic relaxation and GI motility.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1528-0012
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1608-17
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pubmed:meshHeading |
pubmed-meshheading:21277853-Animals,
pubmed-meshheading:21277853-Cyclic GMP-Dependent Protein Kinases,
pubmed-meshheading:21277853-Gastrointestinal Motility,
pubmed-meshheading:21277853-Guanylate Cyclase,
pubmed-meshheading:21277853-Immunohistochemistry,
pubmed-meshheading:21277853-Intestines,
pubmed-meshheading:21277853-Mice,
pubmed-meshheading:21277853-Mice, Knockout,
pubmed-meshheading:21277853-Muscle Relaxation,
pubmed-meshheading:21277853-Myocytes, Smooth Muscle,
pubmed-meshheading:21277853-Nitric Oxide,
pubmed-meshheading:21277853-Signal Transduction
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pubmed:year |
2011
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pubmed:articleTitle |
Nitric oxide-sensitive guanylyl cyclase is dispensable for nitrergic signaling and gut motility in mouse intestinal smooth muscle.
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pubmed:affiliation |
Physiologisches Institut, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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