Linked Life Data

21276846

Source:http://linkedlifedata.com/resource/pubmed/id/21276846

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pubmed-article:21276846pubmed:abstractTextAtherosclerosis is accompanied by the proliferation of human aortic smooth muscle cells (HASMC) and their movement into the intima. Many reports have indicated the involvement of gelatinases (MMP-9 and MMP-2) in this pathogenesis. The ethylacetate fraction from starfish, Asterias amurensis (EFA), harvested from the Korean seaside has an inhibitory effect on MMP-9 and MMP-2 activities, as well as on the expression of MMP-9 in TNF-? induced HASMC in a dose-dependent manner. Also, EFA inhibits the migration of TNF-? induced HASMC in transwells containing gelatin coated plugs. EFA was not cytotoxic to HASMC over the range 0-1mg/ml. By Western-blot analysis, it was revealed that the phosphorylation of extracellular signal regulated kinase (ERK) in TNF-? induced cells was inhibited and nuclear factor kappa B (NF-?B) p65 levels in nuclear extracts were decreased by EFA treatment. In addition, ERK inhibitor (U0126) treated cells exhibited decreased MMP-9 activity in the zymographic assay. From these results, it was found that the gelatinolytic activity was regulated (1) by enzymatic inhibition of both MMP-9 and MMP-2, as well as (2) by the decreased production of MMP-9 via ERK pathways in EFA treated HASMCs. Taken together, it has been shown that EFA has a putative anti-atherosclerotic effect.lld:pubmed
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pubmed-article:21276846pubmed:authorpubmed-author:LeeYoung-Choo...lld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:KimCheorl-HoC...lld:pubmed
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pubmed-article:21276846pubmed:authorpubmed-author:ChangYoung-Ch...lld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:NaMin-KyunMKlld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:KimJeong-RanJ...lld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:SuhSeok-JongS...lld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:ParkSung-JaeS...lld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:YangJu HyeJHlld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:SongKwon-HoKHlld:pubmed
pubmed-article:21276846pubmed:authorpubmed-author:KwonKyung-Min...lld:pubmed
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pubmed-article:21276846pubmed:copyrightInfoCopyright © 2011 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:21276846pubmed:articleTitleEthylacetate fraction from Korean seaside starfish, Asterias amurensis, has an inhibitory effect on MMP-9 activity and expression and on migration behavior of TNF-? induced human aortic smooth muscle cells.lld:pubmed
pubmed-article:21276846pubmed:affiliationCollege of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.lld:pubmed
pubmed-article:21276846pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21276846pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed