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pubmed-article:21276244pubmed:abstractTextMethylphenidate blocks the re-uptake of dopamine by binding to the dopamine transporter in the presynaptic cell membrane and increases extracellular dopamine levels. Similarities in neuropsychologic effects between nicotine and methylphenidate make it an intriguing potential therapeutic option. Previous research of methylphenidate in smokers has suggested a possible beneficial effect for the relief of nicotine withdrawal symptoms, but showed no efficacy in helping smokers with attention deficit hyperactivity disorder (ADHD) to stop smoking.lld:pubmed
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pubmed-article:21276244pubmed:articleTitleMethylphenidate for treating tobacco dependence in non-attention deficit hyperactivity disorder smokers: a pilot randomized placebo-controlled trial.lld:pubmed
pubmed-article:21276244pubmed:affiliationNicotine Dependence Center, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA. rhurt@mayo.edulld:pubmed
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