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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-31
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pubmed:abstractText |
Although thyroid nodules are common and diagnosed in over 5% of the adult population, only 5% harbor malignancy. Patients with clinically suspicious thyroid nodules need to undergo fine-needle aspiration biopsy (FNAB). The main limitation of FNAB remains indeterminate cytopathology. Only 20%-30% of the indeterminate nodules harbor malignancy, and therefore up to 80% of patients undergo unnecessary thyroidectomy. The aim of this study was to identify and validate a panel of microRNAs (miRNAs) that could serve as a platform for an FNAB-based diagnostic for thyroid neoplasms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1557-9077
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pubmed:author |
pubmed-author:ArielIlanaI,
pubmed-author:EidAhmedA,
pubmed-author:FreundHerbert RHR,
pubmed-author:HalleDavidD,
pubmed-author:IlyayevNadiaN,
pubmed-author:MazehHaggiH,
pubmed-author:Mitrani-RosenbaumStellaS,
pubmed-author:MizrahiIdoI,
pubmed-author:NissanAviramA,
pubmed-author:RoistacherMarinaM,
pubmed-author:StojadinovicAlexanderA,
pubmed-author:TrinkBarryB
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pubmed:issnType |
Electronic
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-8
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pubmed:meshHeading |
pubmed-meshheading:21275764-Adult,
pubmed-meshheading:21275764-Aged,
pubmed-meshheading:21275764-Biopsy, Fine-Needle,
pubmed-meshheading:21275764-Case-Control Studies,
pubmed-meshheading:21275764-Female,
pubmed-meshheading:21275764-Humans,
pubmed-meshheading:21275764-Male,
pubmed-meshheading:21275764-MicroRNAs,
pubmed-meshheading:21275764-Middle Aged,
pubmed-meshheading:21275764-Predictive Value of Tests,
pubmed-meshheading:21275764-RNA, Neoplasm,
pubmed-meshheading:21275764-Reproducibility of Results,
pubmed-meshheading:21275764-Sensitivity and Specificity,
pubmed-meshheading:21275764-Thyroid Neoplasms
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pubmed:year |
2011
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pubmed:articleTitle |
Development of a microRNA-based molecular assay for the detection of papillary thyroid carcinoma in aspiration biopsy samples.
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pubmed:affiliation |
Department of Surgery, Hadassah-Hebrew University Medical Center , Mount Scopus, Jerusalem, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
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