Source:http://linkedlifedata.com/resource/pubmed/id/21274869
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-1-28
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| pubmed:abstractText |
Liver transplantation (LT) has become an accepted therapy for end-stage liver disease in human immunodeficiency virus-positive (HIV+) patients, but the specific results of LT for hepatocellular carcinoma (HCC) are unknown. Between 2003 and 2008, 21 HIV+ patients and 65 HIV- patients with HCC were listed for LT at a single institution. Patient characteristics and pathological features were analyzed. Univariate analysis for overall survival (OS) and recurrence-free survival (RFS) after LT was applied to identify the impact of HIV infection. HIV+ patients were younger than HIV- patients [median age: 48 (range = 41-63 years) versus 57 years (range = 37-72 years), P < 0.001] and had a higher alpha-fetoprotein (AFP) level [median AFP level: 16 (range = 3-7154 ?g/L] versus 13 ?g/L (range = 1-552 ?g/L), P = 0.04]. There was a trend toward a higher dropout rate among HIV+ patients (5/21, 23%) versus HIV- patients (7/65, 10%, P = 0.08). Sixteen HIV+ patients and 58 HIV- patients underwent transplantation after median waiting times of 3.5 (range = 0.5-26 months) and 2.0 months (range = 0.5-24 months, P = 0.18), respectively. No significant difference was observed in the pathological features of HCC. With median follow-up times of 27 (range = 5-74 months) and 36 months (range = 3-82 months, P = 0.40), OS after LT at 1 and 3 years reached 81% and 74% in HIV+ patients and 93% and 85% in HIV- patients, respectively (P = 0.08). RFS rates at 1 and 3 years were 69% and 69% in HIV+ patients and 89% and 84% in HIV- patients, respectively (P = 0.09). In univariate analysis, HIV status did not emerge as a prognostic factor for OS or RFS. CONCLUSION: Because of a higher dropout rate among HIV+ patients, HIV infection impaired the results of LT for HCC on an intent-to-treat basis but had no significant impact on OS and RFS after LT.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1527-3350
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 American Association for the Study of Liver Diseases.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
53
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
475-82
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| pubmed:dateRevised |
2011-7-15
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| pubmed:meshHeading |
pubmed-meshheading:21274869-Adult,
pubmed-meshheading:21274869-Aged,
pubmed-meshheading:21274869-Carcinoma, Hepatocellular,
pubmed-meshheading:21274869-Comorbidity,
pubmed-meshheading:21274869-Female,
pubmed-meshheading:21274869-HIV Infections,
pubmed-meshheading:21274869-Hepatitis B,
pubmed-meshheading:21274869-Hepatitis C,
pubmed-meshheading:21274869-Humans,
pubmed-meshheading:21274869-Liver Neoplasms,
pubmed-meshheading:21274869-Liver Transplantation,
pubmed-meshheading:21274869-Male,
pubmed-meshheading:21274869-Middle Aged,
pubmed-meshheading:21274869-Neoplasm Recurrence, Local,
pubmed-meshheading:21274869-Prognosis,
pubmed-meshheading:21274869-Retrospective Studies,
pubmed-meshheading:21274869-Survival Rate,
pubmed-meshheading:21274869-Treatment Outcome
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| pubmed:year |
2011
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| pubmed:articleTitle |
Liver transplantation for hepatocellular carcinoma: the impact of human immunodeficiency virus infection.
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| pubmed:affiliation |
Centre Hepato-Biliaire, AP-HP Hôpital Paul Brousse, Villejuif, France.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|