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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
It has been reported that continuous low-dose (metronomic) administration of cytotoxic drugs may be better tolerated and may have greater antitumor effects than a single high-dose chemotherapy. The aim of this study was to examine the efficacy and cardiotoxicity of metronomic administration of two of the most commonly used anticancer agents, cyclophosphamide (CPA) and doxorubicin (DOX), on an experimental breast cancer of rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1791-7530
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-20
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pubmed:meshHeading |
pubmed-meshheading:21273601-Adenocarcinoma,
pubmed-meshheading:21273601-Animals,
pubmed-meshheading:21273601-Antibiotics, Antineoplastic,
pubmed-meshheading:21273601-Antineoplastic Agents, Alkylating,
pubmed-meshheading:21273601-Body Weight,
pubmed-meshheading:21273601-Cyclophosphamide,
pubmed-meshheading:21273601-Dose-Response Relationship, Drug,
pubmed-meshheading:21273601-Doxorubicin,
pubmed-meshheading:21273601-Echocardiography,
pubmed-meshheading:21273601-Female,
pubmed-meshheading:21273601-Heart,
pubmed-meshheading:21273601-Mammary Neoplasms, Experimental,
pubmed-meshheading:21273601-Rats,
pubmed-meshheading:21273601-Rats, Inbred F344,
pubmed-meshheading:21273601-Troponin I,
pubmed-meshheading:21273601-Tumor Cells, Cultured
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pubmed:year |
2011
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pubmed:articleTitle |
Increased efficacy and reduced cardiotoxicity of metronomic treatment with cyclophosphamide in rat breast cancer.
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pubmed:affiliation |
Department of Surgery, Division of Breast Surgical Oncology, Little Rock, AR 72205, USA. todorovavalentinak@uams.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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