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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-17
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pubmed:abstractText |
Histamine and histamine receptors are found in atherosclerotic lesions, and their signaling and subsequent proatherogenic or proinflammatory gene expression are involved in atherogenesis. In the present study, we generated apolipoprotein E (apoE) and histamine synthesizing histidine decarboxylase double knockout (DKO) mice on a C57BL/6J (wild-type mice) background to clarify the roles of histamine in atherosclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histidine Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:DingYanY,
pubmed-author:HiranoKen-IchiK,
pubmed-author:KatoSeiyaS,
pubmed-author:KohnoKimitoshiK,
pubmed-author:MurataYoshitakaY,
pubmed-author:OhtsuHiroshiH,
pubmed-author:RinG DGD,
pubmed-author:SasaguriYasuyukiY,
pubmed-author:ShimajiriShoheiS,
pubmed-author:TanimotoAkihideA,
pubmed-author:TsutsuiMasatoM,
pubmed-author:WangKe-YongKY,
pubmed-author:WatanabeTeruoT,
pubmed-author:YamadaSohsukeS
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
800-7
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pubmed:meshHeading |
pubmed-meshheading:21273563-Animals,
pubmed-meshheading:21273563-Aortic Diseases,
pubmed-meshheading:21273563-Apolipoproteins E,
pubmed-meshheading:21273563-Atherosclerosis,
pubmed-meshheading:21273563-Blotting, Western,
pubmed-meshheading:21273563-Cholesterol,
pubmed-meshheading:21273563-Cholesterol, Dietary,
pubmed-meshheading:21273563-Cytokines,
pubmed-meshheading:21273563-Disease Models, Animal,
pubmed-meshheading:21273563-Gene Expression Regulation,
pubmed-meshheading:21273563-Genotype,
pubmed-meshheading:21273563-Histamine,
pubmed-meshheading:21273563-Histidine Decarboxylase,
pubmed-meshheading:21273563-Hyperlipidemias,
pubmed-meshheading:21273563-Immunohistochemistry,
pubmed-meshheading:21273563-Inflammation,
pubmed-meshheading:21273563-Inflammation Mediators,
pubmed-meshheading:21273563-Male,
pubmed-meshheading:21273563-Matrix Metalloproteinases,
pubmed-meshheading:21273563-Mice,
pubmed-meshheading:21273563-Mice, Inbred C57BL,
pubmed-meshheading:21273563-Mice, Knockout,
pubmed-meshheading:21273563-NF-kappa B,
pubmed-meshheading:21273563-Phenotype,
pubmed-meshheading:21273563-Receptors, Histamine,
pubmed-meshheading:21273563-Receptors, Scavenger,
pubmed-meshheading:21273563-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2011
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pubmed:articleTitle |
Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level.
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pubmed:affiliation |
Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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