Linked Life Data

2127304

Source:http://linkedlifedata.com/resource/pubmed/id/2127304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-4-9
pubmed:abstractText
Using a single electrode voltage clamp technique the actions of rapidly superfused thyrotropin-releasing hormone (TRH, 1 microM) on lumbar motoneurones of the isolated neonatal rat spinal cord were investigated. TRH induced a slowly developing inward current (associated with an input conductance fall) with slow recovery on washout. In the presence of TRH the normally linear current-voltage relations displayed strong inward rectification up to about -40 mV. The TRH-induced current peaked at -50 mV, reversed at -120 mV and was not blocked by Cs+, tetraethylammonium, 4-aminopyridine, Cd2+, or low Na+. Its reversal potential was sensitive to changes in extracellular K+. Ba2+ (0.2-1.5 mM) depressed the effects of TRH. It is suggested that in rat motoneurones TRH blocked an apparently novel K+ conductance (IK(T)) active at resting membrane potential.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Block by the neuropeptide TRH of an apparently novel K+ conductance of rat motoneurones.
pubmed:affiliation
Department of Pharmacology, St. Bartholomew's Hospital Medical College, University of London, U.K.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't