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pubmed-article:21272337pubmed:abstractTextHuman respiratory syncytial virus (RSV) causes severe respiratory disease in infants. Airway epithelial cells are the principle targets of RSV infection. However, the mechanisms by which it causes disease are poorly understood. Most RSV pathogenesis data are derived using laboratory-adapted prototypic strains. We hypothesized that such strains may be poorly representative of recent clinical isolates in terms of virus/host interactions in primary human bronchial epithelial cells (PBECs).lld:pubmed
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pubmed-article:21272337pubmed:articleTitleDifferential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells.lld:pubmed
pubmed-article:21272337pubmed:affiliationCentre for Infection & Immunity, School of Medicine, Dentistry & Biomedical Sciences, Queens University Belfast, Belfast BT9 7BL, Northern Ireland.lld:pubmed
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pubmed-article:21272337pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed