Linked Life Data

21272035

Source:http://linkedlifedata.com/resource/pubmed/id/21272035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-6-2
pubmed:abstractText
Aggregation of the high-affinity IgE receptor (Fc?RI) with the low-affinity IgG receptor (Fc?RIIb) on basophils or mast cells has been shown to inhibit allergen-induced cell degranulation. Molecules cross-linking these two receptors might therefore be of interest for the treatment of allergic disorders. Here, we demonstrate the generation of a novel bispecific fusion protein efficiently aggregating Fc?RI-bound IgE with Fc?RIIb on the surface of basophils to prevent pro-inflammatory mediator release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1398-9995
pubmed:author
pubmed:copyrightInfo
© 2011 John Wiley & Sons A/S.
pubmed:issnType
Electronic
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
961-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein.
pubmed:affiliation
University Institute of Immunology, University of Bern, Inselspital, Bern Molecular Partners AG, Zürich-Schlieren, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't