Source:http://linkedlifedata.com/resource/pubmed/id/21270826
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-4-22
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| pubmed:abstractText |
The NZM2410-derived Sle2 lupus susceptibility locus induces an abnormal B-cell differentiation, which most prominently leads to the expansion of autoreactive B1a cells. We have mapped the expansion of B1a cells to three Sle2 sub-loci, Sle2a, Sle2b and Sle2c. Sle2 also enhances the breach of B-cell tolerance to nuclear antigens in the 56R anti-DNA immunoglobulin transgenic (Tg) model. This study used the Sle2 sub-congenic strains to map the activation of 56R Tg B cells. Sle2c strongly sustained the breach of tolerance and the activation of anti-DNA B cells. The production of Tg-encoded anti-DNA antibodies was more modest in Sle2a-expressing mice, but Sle2a was responsible for the recruitment for Tg B cells to the marginal zone, a phenotype that has been found for 56R Tg B cells in mice expressing the whole Sle2 interval. In addition, Sle2a promoted the production of endogenously encoded anti-DNA antibodies. Overall, this study showed that at least two Sle2 genes are involved in the activation of anti-DNA B cells, and excluded more than two-thirds of the Sle2 interval from contributing to this phenotype. This constitutes an important step toward the identification of novel genes that have a critical role in B-cell tolerance.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1476-5470
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
199-207
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| pubmed:meshHeading |
pubmed-meshheading:21270826-Animals,
pubmed-meshheading:21270826-Antibodies, Antinuclear,
pubmed-meshheading:21270826-B-Lymphocytes,
pubmed-meshheading:21270826-Disease Models, Animal,
pubmed-meshheading:21270826-Female,
pubmed-meshheading:21270826-Gene Order,
pubmed-meshheading:21270826-Genetic Predisposition to Disease,
pubmed-meshheading:21270826-Immunoglobulin Isotypes,
pubmed-meshheading:21270826-Lupus Erythematosus, Systemic,
pubmed-meshheading:21270826-Lymphocyte Activation,
pubmed-meshheading:21270826-Male,
pubmed-meshheading:21270826-Mice,
pubmed-meshheading:21270826-Mice, Inbred C57BL,
pubmed-meshheading:21270826-Mice, Inbred NZB,
pubmed-meshheading:21270826-Mice, Transgenic,
pubmed-meshheading:21270826-Phenotype,
pubmed-meshheading:21270826-Quantitative Trait Loci,
pubmed-meshheading:21270826-Spleen
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes.
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| pubmed:affiliation |
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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