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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-1
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pubmed:abstractText |
Genetic defects in human pericentrin (PCNT), encoding the centrosomal protein pericentrin, cause a form of osteodysplastic primordial dwarfism that is sometimes reported to be associated with diabetes. We thus set out to determine the prevalence of diabetes and insulin resistance among patients with PCNT defects and examined the effects of pericentrin depletion on insulin action using 3T3-L1 adipocytes as a model system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:BicknellLouise SLS,
pubmed-author:BoberMichaelM,
pubmed-author:FinucaneFrancis MFM,
pubmed-author:Huang-DoranIsabelI,
pubmed-author:JacksonAndrew PAP,
pubmed-author:KrookAnnaA,
pubmed-author:Majewski Osteodysplastic Primordial Dwarfism Study Group,
pubmed-author:NolanJohn JJJ,
pubmed-author:O'DriscollMarkM,
pubmed-author:O'RahillyStephenS,
pubmed-author:PorterKeith MKM,
pubmed-author:RochaNunoN,
pubmed-author:SempleRobert KRK,
pubmed-author:SzekeresFerencF,
pubmed-author:TungY C LoraineYC
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
925-35
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pubmed:meshHeading |
pubmed-meshheading:21270239-3T3-L1 Cells,
pubmed-meshheading:21270239-Adipocytes,
pubmed-meshheading:21270239-Adipogenesis,
pubmed-meshheading:21270239-Adult,
pubmed-meshheading:21270239-Analysis of Variance,
pubmed-meshheading:21270239-Animals,
pubmed-meshheading:21270239-Antigens,
pubmed-meshheading:21270239-Blotting, Western,
pubmed-meshheading:21270239-Body Composition,
pubmed-meshheading:21270239-Child,
pubmed-meshheading:21270239-Diabetes Mellitus,
pubmed-meshheading:21270239-Female,
pubmed-meshheading:21270239-Gene Expression,
pubmed-meshheading:21270239-Humans,
pubmed-meshheading:21270239-Immunohistochemistry,
pubmed-meshheading:21270239-Insulin Resistance,
pubmed-meshheading:21270239-Male,
pubmed-meshheading:21270239-Mice,
pubmed-meshheading:21270239-Signal Transduction
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pubmed:year |
2011
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pubmed:articleTitle |
Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes.
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pubmed:affiliation |
Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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