|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2011-6-1
|
|
pubmed:abstractText |
Th17 cells represent a novel subset of CD4(+) T cells, which is associated with Helicobacter pylori infection. In the present study, we investigated the potential role of Urease subunit B (UreB) in the induction of Th17 cell response. Co-cultured splenic lymphocytes from H. pylori-infected mice with the recombinant UreB (rUreB) elevated IL-17 secretion and caused an increase in the number of Th17 cells. The expression of IL-6 and IL-23 p19 was significantly increased in rUreB-stimulated macrophages. Whole cell protein (WCP) of UreB-deficient strain (UreB(-) strain) induced less Th17 cell responses than that of wild-type strain. In addition, subcutaneous and intranasal immunization of rUreB elicited antigen-specific Th17 cell responses. Intranasal immunization of rUreB reduced H. pylori colonization in the stomach, which was closely related with the increased rUreB-specific Th17 cell responses. These results suggest that UreB is an important protein which is able to elicit Th17 cell responses against H. pylori both in vivo and in vitro.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1878-3279
|
|
pubmed:author |
pubmed-author:ChenLiL,
pubmed-author:ChenRuR,
pubmed-author:GatiJ SJS,
pubmed-author:GuoHongH,
pubmed-author:JunJanJ,
pubmed-author:LiuXiao-FeiXF,
pubmed-author:MaoXu-HuXH,
pubmed-author:PeggS NSN,
pubmed-author:TangBinB,
pubmed-author:YuShuS,
pubmed-author:YuanZhuangZ,
pubmed-author:YunShiS,
pubmed-author:ZAKR LRL,
pubmed-author:ZhangJin-YuJY,
pubmed-author:ZouQuan-MingQM
|
|
pubmed:copyrightInfo |
Copyright © 2010 Elsevier GmbH. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
216
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
803-10
|
|
pubmed:meshHeading |
pubmed-meshheading:21269729-Animals,
pubmed-meshheading:21269729-Bacterial Proteins,
pubmed-meshheading:21269729-Cell Proliferation,
pubmed-meshheading:21269729-Cells, Cultured,
pubmed-meshheading:21269729-Cytokines,
pubmed-meshheading:21269729-Helicobacter Infections,
pubmed-meshheading:21269729-Helicobacter pylori,
pubmed-meshheading:21269729-Lymphocyte Activation,
pubmed-meshheading:21269729-Macrophages,
pubmed-meshheading:21269729-Male,
pubmed-meshheading:21269729-Mice,
pubmed-meshheading:21269729-Mice, Inbred BALB C,
pubmed-meshheading:21269729-Mutation,
pubmed-meshheading:21269729-Protein Subunits,
pubmed-meshheading:21269729-Recombinant Proteins,
pubmed-meshheading:21269729-Stomach,
pubmed-meshheading:21269729-Th17 Cells,
pubmed-meshheading:21269729-Urease
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Induction of a Th17 cell response by Helicobacter pylori Urease subunit B.
|
|
pubmed:affiliation |
Department of Clinical Microbiology and Immunology, College of Medical Laboratory, The Third Military Medical University, Chongqing, PR China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
