Linked Life Data

21268129

Source:http://linkedlifedata.com/resource/pubmed/id/21268129

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pubmed-article:21268129pubmed:dateCreated2011-6-7lld:pubmed
pubmed-article:21268129pubmed:abstractTextInvestigation of potential association of SNPs (G870A, rs9344; G1722C, rs678653) of cyclin D1 gene (CCND1) with susceptibility to esophageal squamous cell carcinoma (ESCC) in Kashmir valley (India). The study included 302 subjects comprising 151 ESCC cases and 151 controls. PCR-RFLP and direct sequencing were employed for genotyping. The G870A polymorphism, the individuals carrying GA?+?AA genotype was having 2.80-fold increased risk for development of ESCC (OR 2.8, 95% CI?=?1.77-4.4; P?=?0.0001) compared to GG genotype. Further a significantly higher risk was observed in individuals who consume >3 cups per day of salted tea (OR?=?5.1; 95% CI?=?1.6-16.7; P?=?0.0016) and had smoking habits (OR?=?6.3; 95% CI?=?2.9-13.9; P?=?0.0005). We also demonstrate for the first time in CCND1 1722 locus, the CC genotype was strongly associated with increased risk of developing ESCC (OR?=?2.58; 95% CI?=?1.61-4.15; P?=?0.0001). In addition, the frequency of polymorphic C allele was also found to be higher in cases (OR?=?1.92; 95% CI?=?1.37-2.69; P?=?0.0002). There appears to be an influence of CCND1 G870A/G1772C genotypes on genetic susceptibility to ESCC.lld:pubmed
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pubmed-article:21268129pubmed:authorpubmed-author:BhatMohammad...lld:pubmed
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pubmed-article:21268129pubmed:authorpubmed-author:YuvarajMMlld:pubmed
pubmed-article:21268129pubmed:copyrightInfoCopyright ©2011 Wiley-Liss, Inc.lld:pubmed
pubmed-article:21268129pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21268129pubmed:volume50lld:pubmed
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pubmed-article:21268129pubmed:pagination487-98lld:pubmed
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pubmed-article:21268129pubmed:year2011lld:pubmed
pubmed-article:21268129pubmed:articleTitleAssociation of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley: a high risk area.lld:pubmed
pubmed-article:21268129pubmed:affiliationDivision of Molecular Genetics and Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India.lld:pubmed
pubmed-article:21268129pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21268129pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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