| pubmed-article:2126688 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2126688 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:2126688 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2126688 | lifeskim:mentions | umls-concept:C0028365 | lld:lifeskim |
| pubmed-article:2126688 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:2126688 | lifeskim:mentions | umls-concept:C0232555 | lld:lifeskim |
| pubmed-article:2126688 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2126688 | pubmed:dateCreated | 1991-3-19 | lld:pubmed |
| pubmed-article:2126688 | pubmed:abstractText | A new type of norfloxacin-resistant mutant of Pseudomonas aeruginosa PAO was isolated. This mutant showed cross resistance to imipenem and chloramphenicol and hypersusceptibility to beta-lactam and aminoglycoside antibiotics. The new norfloxacin resistance gene nfxC was mapped near catA (46 min) on the PAO chromosome. Norfloxacin accumulation was decreased in the nfxC mutant; furthermore, the rate of imipenem diffusion through the outer membrane of the nfxC mutant was lower than that of the parent strain. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of outer membrane proteins showed a decrease of a 46-kilodalton protein and an increase of a 50-kilodalton protein in the nfxC mutant. We conclude the nfxC is a new norfloxacin resistance gene that affects outer membrane permeability to quinolones and other antimicrobial agents. | lld:pubmed |
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| pubmed-article:2126688 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2126688 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2126688 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2126688 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2126688 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2126688 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2126688 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:2126688 | pubmed:author | pubmed-author:IyobeSS | lld:pubmed |
| pubmed-article:2126688 | pubmed:author | pubmed-author:FukudaHH | lld:pubmed |
| pubmed-article:2126688 | pubmed:author | pubmed-author:HiraiKK | lld:pubmed |
| pubmed-article:2126688 | pubmed:author | pubmed-author:HosakaMM | lld:pubmed |
| pubmed-article:2126688 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2126688 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:2126688 | pubmed:geneSymbol | nalA | lld:pubmed |
| pubmed-article:2126688 | pubmed:geneSymbol | nfxB | lld:pubmed |
| pubmed-article:2126688 | pubmed:geneSymbol | cfxA | lld:pubmed |
| pubmed-article:2126688 | pubmed:geneSymbol | cfxB | lld:pubmed |
| pubmed-article:2126688 | pubmed:geneSymbol | nfxA | lld:pubmed |
| pubmed-article:2126688 | pubmed:geneSymbol | nfxC | lld:pubmed |
| pubmed-article:2126688 | pubmed:geneSymbol | nalB | lld:pubmed |
| pubmed-article:2126688 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2126688 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2126688 | pubmed:pagination | 1757-61 | lld:pubmed |
| pubmed-article:2126688 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2126688 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2126688 | pubmed:articleTitle | New norfloxacin resistance gene in Pseudomonas aeruginosa PAO. | lld:pubmed |
| pubmed-article:2126688 | pubmed:affiliation | Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Tochigi-ken, Japan. | lld:pubmed |
| pubmed-article:2126688 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2126688 | pubmed:publicationType | Comparative Study | lld:pubmed |
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