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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1991-3-19
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pubmed:abstractText |
A new type of norfloxacin-resistant mutant of Pseudomonas aeruginosa PAO was isolated. This mutant showed cross resistance to imipenem and chloramphenicol and hypersusceptibility to beta-lactam and aminoglycoside antibiotics. The new norfloxacin resistance gene nfxC was mapped near catA (46 min) on the PAO chromosome. Norfloxacin accumulation was decreased in the nfxC mutant; furthermore, the rate of imipenem diffusion through the outer membrane of the nfxC mutant was lower than that of the parent strain. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of outer membrane proteins showed a decrease of a 46-kilodalton protein and an increase of a 50-kilodalton protein in the nfxC mutant. We conclude the nfxC is a new norfloxacin resistance gene that affects outer membrane permeability to quinolones and other antimicrobial agents.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-101518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-104142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-118160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2461164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2496655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2502066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2546493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2580479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2829712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2837141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2843087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-2982966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3010850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3026239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3032915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3088133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3111356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3111361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3124739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3125787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-337300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3512733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-3532944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-6307974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-6800884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2126688-6821455
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0066-4804
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:geneSymbol |
cfxA,
cfxB,
nalA,
nalB,
nfxA,
nfxB,
nfxC
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1757-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2126688-Bacterial Outer Membrane Proteins,
pubmed-meshheading:2126688-Cell Membrane,
pubmed-meshheading:2126688-Chromosome Mapping,
pubmed-meshheading:2126688-Drug Resistance, Microbial,
pubmed-meshheading:2126688-Imipenem,
pubmed-meshheading:2126688-Microbial Sensitivity Tests,
pubmed-meshheading:2126688-Mutation,
pubmed-meshheading:2126688-Norfloxacin,
pubmed-meshheading:2126688-Permeability,
pubmed-meshheading:2126688-Pseudomonas aeruginosa
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pubmed:year |
1990
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pubmed:articleTitle |
New norfloxacin resistance gene in Pseudomonas aeruginosa PAO.
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pubmed:affiliation |
Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Tochigi-ken, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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