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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-3-17
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pubmed:abstractText |
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of aggressive lymphomas with the activated B-cell-like subtype characterized by constitutive NF-?B activation. Activating mutations of CARD11 and inactivating mutations of A20 are frequent events in DLBCL. However, the full extent of genetic alterations in the NF-?B pathway regulators and their potential prognostic value in DLBCL remain to be investigated. We investigated the genetic abnormalities of CARD11, A20, and ABIN-1/2/3 (the A20 binding inhibitor of NF-?B) and their clinicopathologic correlation in gastrointestinal DLBCL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/CARD Signaling Adaptor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CARD11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL20,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/TNIP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNIP2 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AppertAlexA,
pubmed-author:AuWing-YanWY,
pubmed-author:ChanudetEstelleE,
pubmed-author:ChenYun-WenYW,
pubmed-author:ChuangShih-SungSS,
pubmed-author:DongGehongG,
pubmed-author:DuMing-QingMQ,
pubmed-author:GaoZifenZ,
pubmed-author:HamoudiRifat ARA,
pubmed-author:LiuHongxiangH,
pubmed-author:SrivastavaGopeshG,
pubmed-author:WatkinsA JamesAJ,
pubmed-author:YeHongtaoH,
pubmed-author:ZengNaiyanN
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pubmed:copyrightInfo |
©2011 AACR.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1440-51
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pubmed:meshHeading |
pubmed-meshheading:21266526-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:21266526-CARD Signaling Adaptor Proteins,
pubmed-meshheading:21266526-Chemokine CCL20,
pubmed-meshheading:21266526-Chromosome Aberrations,
pubmed-meshheading:21266526-DNA-Binding Proteins,
pubmed-meshheading:21266526-Gastrointestinal Neoplasms,
pubmed-meshheading:21266526-Guanylate Cyclase,
pubmed-meshheading:21266526-Humans,
pubmed-meshheading:21266526-Immunoprecipitation,
pubmed-meshheading:21266526-In Situ Hybridization, Fluorescence,
pubmed-meshheading:21266526-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:21266526-Mutation,
pubmed-meshheading:21266526-NF-kappa B,
pubmed-meshheading:21266526-Prognosis,
pubmed-meshheading:21266526-Promoter Regions, Genetic,
pubmed-meshheading:21266526-Sequence Analysis, DNA
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pubmed:year |
2011
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pubmed:articleTitle |
A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.
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pubmed:affiliation |
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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