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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-1
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pubmed:abstractText |
Obesity-associated insulin resistance is characterized by a state of chronic, low-grade inflammation that is associated with the accumulation of M1 proinflammatory macrophages in adipose tissue. Although different evidence explains the mechanisms linking the expansion of adipose tissue and adipose tissue macrophage (ATM) polarization, in the current study we investigated the concept of lipid-induced toxicity as the pathogenic link that could explain the trigger of this response.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:BarbarrojaNuriaN,
pubmed-author:CamachoAlbertoA,
pubmed-author:DopazoJoaquinJ,
pubmed-author:FuentesLucíaL,
pubmed-author:IshikawaKoK,
pubmed-author:MokCrystal Y LCY,
pubmed-author:MontanerDavidD,
pubmed-author:NúñezVanessaV,
pubmed-author:O'RahillyStephenS,
pubmed-author:Oreši?MatejM,
pubmed-author:PrieurXavierX,
pubmed-author:RicoteMercedesM,
pubmed-author:SethiJaswinder KJK,
pubmed-author:VelagapudiVidya RVR,
pubmed-author:Vidal-PuigAntonioA
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
797-809
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pubmed:meshHeading |
pubmed-meshheading:21266330-Adipocytes,
pubmed-meshheading:21266330-Adipose Tissue,
pubmed-meshheading:21266330-Animals,
pubmed-meshheading:21266330-Cell Fractionation,
pubmed-meshheading:21266330-Cells, Cultured,
pubmed-meshheading:21266330-Diet,
pubmed-meshheading:21266330-Flow Cytometry,
pubmed-meshheading:21266330-Gene Expression Profiling,
pubmed-meshheading:21266330-Inflammation,
pubmed-meshheading:21266330-Insulin Resistance,
pubmed-meshheading:21266330-Lipid Metabolism,
pubmed-meshheading:21266330-Macrophages,
pubmed-meshheading:21266330-Mice,
pubmed-meshheading:21266330-Mice, Obese,
pubmed-meshheading:21266330-Obesity,
pubmed-meshheading:21266330-Oligonucleotide Array Sequence Analysis
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pubmed:year |
2011
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pubmed:articleTitle |
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice.
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pubmed:affiliation |
Institute of Metabolic Science, Metabolic Research Laboratories, and Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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