21266327

Source:http://linkedlifedata.com/resource/pubmed/id/21266327

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014653, umls-concept:C0162658, umls-concept:C0205224, umls-concept:C1314677, umls-concept:C1514485
pubmed:issue	3
pubmed:dateCreated	2011-3-1
pubmed:abstractText	We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both ?-cell mass and function.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA-68485, http://linkedlifedata.com/resource/pubmed/grant/DK-20593, http://linkedlifedata.com/resource/pubmed/grant/DK-42502, http://linkedlifedata.com/resource/pubmed/grant/DK-58404, http://linkedlifedata.com/resource/pubmed/grant/DK-59637, http://linkedlifedata.com/resource/pubmed/grant/EY-08126, http://linkedlifedata.com/resource/pubmed/grant/HD-15052
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372763
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glucose, http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Pten protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/rictor protein, mouse
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1939-327X
pubmed:author	pubmed-author:GuYanyunY, pubmed-author:KumarAnilA, pubmed-author:LindnerJillJ, pubmed-author:MagnusonMark AMA, pubmed-author:YuanWeipingW
pubmed:issnType	Electronic
pubmed:volume	60
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	827-37
pubmed:meshHeading	pubmed-meshheading:21266327-Alleles, pubmed-meshheading:21266327-Analysis of Variance, pubmed-meshheading:21266327-Animals, pubmed-meshheading:21266327-Apoptosis, pubmed-meshheading:21266327-Blotting, Western, pubmed-meshheading:21266327-Carrier Proteins, pubmed-meshheading:21266327-Cell Proliferation, pubmed-meshheading:21266327-Cell Size, pubmed-meshheading:21266327-Fluorescent Antibody Technique, pubmed-meshheading:21266327-Genotype, pubmed-meshheading:21266327-Glucose, pubmed-meshheading:21266327-Glucose Intolerance, pubmed-meshheading:21266327-Hyperglycemia, pubmed-meshheading:21266327-Insulin-Secreting Cells, pubmed-meshheading:21266327-Mice, pubmed-meshheading:21266327-Mice, Knockout, pubmed-meshheading:21266327-PTEN Phosphohydrolase, pubmed-meshheading:21266327-Phosphorylation, pubmed-meshheading:21266327-Proto-Oncogene Proteins c-akt, pubmed-meshheading:21266327-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:21266327-Signal Transduction
pubmed:year	2011
pubmed:articleTitle	Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
pubmed:affiliation	Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural