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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1991-3-19
|
| pubmed:abstractText |
Resistance to third-generation cephalosporins occurs as a result of either the production of high concentrations of chromosomal cephalosporinase or, increasingly, the presence of broad-spectrum plasmid-mediated beta-lactamases. Both cases represent the response of bacteria in the hospital setting to the selection pressure brought to bear by the use of these antibiotics. Continued evolution of the plasmid-mediated enzymes is occurring as new antibiotics are introduced, probably reflecting the process that began when the first beta-lactamase apparently evolved from the penicillin-binding proteins. beta-Lactamase inhibitors offer one approach to dealing with the evolution of resistance to previously beta-lactamase-stable antibiotics.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-0605
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18 Suppl 4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
37D-47D
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading |
pubmed-meshheading:2126509-Amino Acid Sequence,
pubmed-meshheading:2126509-Anti-Bacterial Agents,
pubmed-meshheading:2126509-Cephalosporinase,
pubmed-meshheading:2126509-Cephalosporins,
pubmed-meshheading:2126509-Chromosomes, Bacterial,
pubmed-meshheading:2126509-Drug Resistance, Microbial,
pubmed-meshheading:2126509-Enterobacteriaceae,
pubmed-meshheading:2126509-Molecular Sequence Data,
pubmed-meshheading:2126509-Pseudomonas aeruginosa,
pubmed-meshheading:2126509-beta-Lactamases
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Evolution of enzymatic mechanisms of resistance among beta-lactam antibiotics.
|
| pubmed:affiliation |
Medical Microbiology Laboratory, Broussais Hospital, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Review
|