Source:http://linkedlifedata.com/resource/pubmed/id/21264940
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2011-4-4
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pubmed:abstractText |
We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22-24 (RLS3) and a later genome-wide association study (GWAS) implicated the PTPRD gene at the RLS3 locus as a susceptibility gene for RLS. However, from the standpoint of genetics, the GWAS association needs to be validated by independent studies. In this study, we used both family-based and population-based association studies to assess the association between PTPRD and RLS in an American Caucasian population.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1531-8257
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2011 Movement Disorder Society.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
516-9
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pubmed:meshHeading |
pubmed-meshheading:21264940-Chi-Square Distribution,
pubmed-meshheading:21264940-Chromosomes, Human, Pair 9,
pubmed-meshheading:21264940-Cohort Studies,
pubmed-meshheading:21264940-Community Health Planning,
pubmed-meshheading:21264940-Family Health,
pubmed-meshheading:21264940-Female,
pubmed-meshheading:21264940-Gene Frequency,
pubmed-meshheading:21264940-Genetic Predisposition to Disease,
pubmed-meshheading:21264940-Genome-Wide Association Study,
pubmed-meshheading:21264940-Genotype,
pubmed-meshheading:21264940-Humans,
pubmed-meshheading:21264940-Male,
pubmed-meshheading:21264940-Polymorphism, Single Nucleotide,
pubmed-meshheading:21264940-Receptor-Like Protein Tyrosine Phosphatases, Class 2,
pubmed-meshheading:21264940-Restless Legs Syndrome,
pubmed-meshheading:21264940-Risk Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome.
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pubmed:affiliation |
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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