rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
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pubmed:dateCreated |
1991-3-12
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pubmed:abstractText |
The inside-out patch clamp technique was used to record the effects of K+ channel openers (EMD 52692, RP 49356 and Cromakalim) on single channel currents in membrane blebs of human skeletal muscle. Two types of K+ channels were activated by these drugs: an ATP-sensitive K+ channel which was inhibited by 3 mM ATP and 5 microM Glibenclamide and an ATP insensitive K+ channel. The open probability of both types was strongly increased by K+ channel openers. Glibenclamide antagonized the action of the K+ channel openers.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Cromakalim,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydropyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Glyburide,
http://linkedlifedata.com/resource/pubmed/chemical/Picolines,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/aprikalim,
http://linkedlifedata.com/resource/pubmed/chemical/bimakalim
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0304-3940
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
13
|
pubmed:volume |
119
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
191-4
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2126363-Adenosine Triphosphate,
pubmed-meshheading:2126363-Benzopyrans,
pubmed-meshheading:2126363-Cromakalim,
pubmed-meshheading:2126363-Dihydropyridines,
pubmed-meshheading:2126363-Electrophysiology,
pubmed-meshheading:2126363-Glyburide,
pubmed-meshheading:2126363-Humans,
pubmed-meshheading:2126363-Muscles,
pubmed-meshheading:2126363-Picolines,
pubmed-meshheading:2126363-Potassium Channels,
pubmed-meshheading:2126363-Pyrans,
pubmed-meshheading:2126363-Pyrroles
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pubmed:year |
1990
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pubmed:articleTitle |
Two different types of potassium channels in human skeletal muscle activated by potassium channel openers.
|
pubmed:affiliation |
Physiologisches Institut, Technischen Universität München, F.R.G.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|