|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2011-1-25
|
|
pubmed:abstractText |
Hemangioblastomas account for up to 2.5% of all intracranial tumors. They may occur sporadically or as a part of the multisystem genetic syndrome of Von Hippel-Lindau syndrome (VHL). Patients with VHL are also at an increased risk of developing clear cell renal cell carcinoma (ccRCC). Distinguishing hemangioblastomas from metastatic ccRCC to the central nervous system (CNS) can be challenging at times when based solely on hematoxylin and eosin-stained sections. We propose an immunohistochemistry (IHC) panel of combination of PAX2, PAX8, and inhibin A as a helpful approach in distinguishing the 2 lesions.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1532-0979
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
262-7
|
|
pubmed:meshHeading |
pubmed-meshheading:21263247-Adolescent,
pubmed-meshheading:21263247-Adult,
pubmed-meshheading:21263247-Aged,
pubmed-meshheading:21263247-Carcinoma, Renal Cell,
pubmed-meshheading:21263247-Cell Nucleus,
pubmed-meshheading:21263247-Central Nervous System Neoplasms,
pubmed-meshheading:21263247-Diagnosis, Differential,
pubmed-meshheading:21263247-Female,
pubmed-meshheading:21263247-Hemangioblastoma,
pubmed-meshheading:21263247-Humans,
pubmed-meshheading:21263247-Inhibins,
pubmed-meshheading:21263247-Kidney Neoplasms,
pubmed-meshheading:21263247-Male,
pubmed-meshheading:21263247-Middle Aged,
pubmed-meshheading:21263247-PAX2 Transcription Factor,
pubmed-meshheading:21263247-Paired Box Transcription Factors,
pubmed-meshheading:21263247-Predictive Value of Tests,
pubmed-meshheading:21263247-Retrospective Studies,
pubmed-meshheading:21263247-Tissue Array Analysis,
pubmed-meshheading:21263247-Tumor Markers, Biological,
pubmed-meshheading:21263247-Young Adult
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
PAX2(-)/PAX8(-)/inhibin A(+) immunoprofile in hemangioblastoma: A helpful combination in the differential diagnosis with metastatic clear cell renal cell carcinoma to the central nervous system.
|
|
pubmed:affiliation |
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA.
|
|
pubmed:publicationType |
Journal Article
|
