| pubmed-article:21262839 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C0292777 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C1412494 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C1425291 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C0205374 | lld:lifeskim |
| pubmed-article:21262839 | lifeskim:mentions | umls-concept:C1519952 | lld:lifeskim |
| pubmed-article:21262839 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21262839 | pubmed:dateCreated | 2011-2-9 | lld:pubmed |
| pubmed-article:21262839 | pubmed:abstractText | Regulatory volume decrease (RVD) is a key mechanism for volume control that serves to prevent detrimental swelling in response to hypo-osmotic stress. The molecular basis of RVD is not understood. Here we show that a complex containing aquaporin-4 (AQP4) and transient receptor potential vanilloid 4 (TRPV4) is essential for RVD in astrocytes. Astrocytes from AQP4-KO mice and astrocytes treated with TRPV4 siRNA fail to respond to hypotonic stress by increased intracellular Ca(2+) and RVD. Coimmunoprecipitation and immunohistochemistry analyses show that AQP4 and TRPV4 interact and colocalize. Functional analysis of an astrocyte-derived cell line expressing TRPV4 but not AQP4 shows that RVD and intracellular Ca(2+) response can be reconstituted by transfection with AQP4 but not with aquaporin-1. Our data indicate that astrocytes contain a TRPV4/AQP4 complex that constitutes a key element in the brain's volume homeostasis by acting as an osmosensor that couples osmotic stress to downstream signaling cascades. | lld:pubmed |
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| pubmed-article:21262839 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21262839 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21262839 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21262839 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21262839 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21262839 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:21262839 | pubmed:author | pubmed-author:CapriniMarcoM | lld:pubmed |
| pubmed-article:21262839 | pubmed:author | pubmed-author:FerroniStefan... | lld:pubmed |
| pubmed-article:21262839 | pubmed:author | pubmed-author:OttersenOle... | lld:pubmed |
| pubmed-article:21262839 | pubmed:author | pubmed-author:Amiry-Moghadd... | lld:pubmed |
| pubmed-article:21262839 | pubmed:author | pubmed-author:BenfenatiVale... | lld:pubmed |
| pubmed-article:21262839 | pubmed:author | pubmed-author:MylonakouMari... | lld:pubmed |
| pubmed-article:21262839 | pubmed:author | pubmed-author:DovizioMelani... | lld:pubmed |
| pubmed-article:21262839 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21262839 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:21262839 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:21262839 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21262839 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21262839 | pubmed:pagination | 2563-8 | lld:pubmed |
| pubmed-article:21262839 | pubmed:dateRevised | 2011-8-25 | lld:pubmed |
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| pubmed-article:21262839 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21262839 | pubmed:articleTitle | An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. | lld:pubmed |
| pubmed-article:21262839 | pubmed:affiliation | Institute for Nanostructured Materials, Consiglio Nazionale delle Ricerche, 40129 Bologna, Italy. | lld:pubmed |
| pubmed-article:21262839 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21262839 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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