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rdf:type |
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|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0004379,
umls-concept:C0008546,
umls-concept:C0083956,
umls-concept:C0221463,
umls-concept:C0337611,
umls-concept:C0450363,
umls-concept:C0600508,
umls-concept:C0740175,
umls-concept:C1516507,
umls-concept:C1516508,
umls-concept:C2257086
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pubmed:issue |
6
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pubmed:dateCreated |
2011-2-9
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pubmed:abstractText |
Regulation of gene expression involves long-distance communication between regulatory elements and target promoters, but how this is achieved remains unknown. Insulator elements have been proposed to modulate the communication between regulatory elements and promoters due to their ability to insulate genes from regulatory elements or to take part in long-distance interactions. Using a high-resolution chromatin conformation capture (H3C) method, we show that the Drosophila gypsy insulator behaves as a conformational chromatin border that is able to prohibit contacts between a Polycomb response element (PRE) and a distal promoter. On the other hand, two spaced gypsy elements form a chromatin loop that is able to bring an upstream PRE in contact with a downstream gene to mediate its repression. Chromatin immunoprecipitation (ChIP) profiles of the Polycomb protein and its associated H3K27me3 histone mark reflect this insulator-dependent chromatin conformation, suggesting that Polycomb action at a distance can be organized by local chromatin topology.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21262819-10412979,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21262819-8382607
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1091-6490
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2294-9
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
|
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pubmed:year |
2011
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pubmed:articleTitle |
A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber.
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pubmed:affiliation |
Institut de Génétique Humaine, Centre National de la Recherche Scientifique Unité Propre de Recherche 1142, 34396 Montpellier Cedex 5, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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