Linked Life Data

2126240

Source:http://linkedlifedata.com/resource/pubmed/id/2126240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-3-14
pubmed:abstractText
In order to investigate the frequency and type of gonadal dysfunction in myotonic dystrophy (MD), we studied 29 patients (13 women and 16 men). In addition to assessment of the basal reproductive hormone status, pituitary sensitivity to GnRH was evaluated with GnRH (Relisorm)-test in 12 (5 women and 7 men) patients with MD, and 10 (5 women and 5 men) control subjects. In two female patients, who had secondary amenorrhea, estradiol provocation test has been performed. Testicular atrophy was found in 13 male patients. The elevated basal FSH levels were observed in 75%, and LH in 43.7% male patients, while testosterone levels were decreased in 37.5% of them. Two female patients had normogonadotropic normoprolactinemic secondary amenorrhea, and four presented oligomenorrhea. Increased basal LH and FSH concentrations, together with the basal estradiol level at the lower limit of normal values, were observed only in one female patient with oligomenorrhea. Hyperprolactinemia has been established in 23.0% female patients. After administration of GnRH, an increased pituitary sensitivity of LH and FSH secretion has been observed in male patients (male patients versus controls: p less than 0.01). The most exaggerated FSH response has been noticed in male patients with increased basal FSH. Significant positive correlation was observed between basal FSH level and maximal FSH increment during GnRH test (r = +0.714; p less than 0.05). An increased response of FSH to GnRH has been also observed in female patients with MD, but when compared to controls, that difference was not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0232-7384
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Gonadal dysfunction in patients with myotonic dystrophy.
pubmed:affiliation
Department of Neurology, University School of Medicine, Belgrade, Yugoslavia.
pubmed:publicationType
Journal Article