Source:http://linkedlifedata.com/resource/pubmed/id/21261439
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-2-8
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| pubmed:abstractText |
In the first part of a series of studies to account for perfluorooctane sulfonate (PFOS)-induced sheep red blood cell (SRBC)-specific immunoglobulin M (IgM) antibody suppression in mice, a survey of clinical and immunotoxicological endpoints was examined. Adult female B?C?F? mice were exposed orally for 28 days to a total administered dose (TAD) of 0, 0.1, 0.5, 1, or 5 mg PFOS/kg. Uterus wet weight was significantly decreased compared with control at the 5 mg/kg dose. No indications of wasting syndrome, malnutrition, alteration of thyroid homeostasis, or signs of overt toxicity were observed. Numbers of splenic CD19+/CD21?, CD19+/CD21+, B220+/CD40+, CD4+/CD154?, CD4+/CD154+, and MHC-II+ cells were not altered. Additionally, ex vivo interleukin-4 (IL-4), IL-5, and IL-6 production by in vitro anti-CD3- or phorbol myristate acetate-stimulated CD4+ T-cells was not affected. Ex vivo IL-6 production by B-cells was significantly increased by in vitro stimulation with either anti-CD40 or lipopolysaccharide. Increased IL-6 production by B-cells was the most sensitive endpoint assessed resulting in alterations at the lowest dose tested (0.1 mg/kg TAD) following anti-CD40 stimulation. Further studies are required to characterize effects on inflammatory markers such as IL-6 at environmentally relevant concentrations of PFOS and to determine the key events associated with PFOS-induced IgM suppression to address potential human health risks.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkanesulfonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Environmental Pollutants,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorocarbons,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroid Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/perfluorooctane sulfonic acid
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1547-6901
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
8
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
17-29
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| pubmed:meshHeading |
pubmed-meshheading:21261439-Alkanesulfonic Acids,
pubmed-meshheading:21261439-Animals,
pubmed-meshheading:21261439-Antigens, CD,
pubmed-meshheading:21261439-B-Lymphocytes,
pubmed-meshheading:21261439-Body Weight,
pubmed-meshheading:21261439-Dose-Response Relationship, Drug,
pubmed-meshheading:21261439-Environmental Pollutants,
pubmed-meshheading:21261439-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21261439-Female,
pubmed-meshheading:21261439-Fluorocarbons,
pubmed-meshheading:21261439-Immunoglobulin M,
pubmed-meshheading:21261439-Interleukin-6,
pubmed-meshheading:21261439-Liver,
pubmed-meshheading:21261439-Mice,
pubmed-meshheading:21261439-Mice, Inbred Strains,
pubmed-meshheading:21261439-Organ Size,
pubmed-meshheading:21261439-Spleen,
pubmed-meshheading:21261439-T-Lymphocytes,
pubmed-meshheading:21261439-Thyroid Hormones,
pubmed-meshheading:21261439-Tissue Distribution
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| pubmed:articleTitle |
Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice.
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| pubmed:affiliation |
National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health & Biomolecular Research, Charleston, SC, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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