Linked Life Data

21258187

Source:http://linkedlifedata.com/resource/pubmed/id/21258187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2011-1-24
pubmed:abstractText
We report a case of a 46-year-old female demonstrating general fatigue and visual disturbances with retinal bleeding. She had a white blood cell count of 419,300/mm. Thereafter, she developed vomiting associated with vertigo caused by cerebellar hemorrhage, deteriorating to acute hydrocephalus secondary to obstruction of the cerebral aqueduct. Emergency procedures for cerebral protection, such as hyperventilation, administration of mannitol, and barbiturate coma, were performed. Bone marrow examination showed a positive BCR-ABL/t(9;22)(q34;q11) chromosomal translocation detected by FISH and RT-PCR (masked Ph) and she was diagnosed as having chronic myeloid leukemia (CML) in the chronic phase (CP). She was administered Ara-C, together with imatinib 600 mg/d through a nasogastric tube. Eight days later, she underwent successful extubation and recovered without any neurological defect. She was maintained on imatinib 400 mg/d and demonstrated a major molecular response at 15 months. Physicians need to be aware that brain hemorrhage may develop as an initial symptom of CML patients in CP.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0485-1439
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1769-74
pubmed:meshHeading
pubmed-meshheading:21258187-Acute Disease, pubmed-meshheading:21258187-Antineoplastic Agents, pubmed-meshheading:21258187-Cerebellum, pubmed-meshheading:21258187-Cerebral Hemorrhage, pubmed-meshheading:21258187-Combined Modality Therapy, pubmed-meshheading:21258187-Cytarabine, pubmed-meshheading:21258187-Drug Therapy, Combination, pubmed-meshheading:21258187-Female, pubmed-meshheading:21258187-Humans, pubmed-meshheading:21258187-Hydrocephalus, pubmed-meshheading:21258187-Intensive Care, pubmed-meshheading:21258187-Leukemia, Myelogenous, Chronic, BCR-ABL Positive, pubmed-meshheading:21258187-Leukostasis, pubmed-meshheading:21258187-Mannitol, pubmed-meshheading:21258187-Middle Aged, pubmed-meshheading:21258187-Piperazines, pubmed-meshheading:21258187-Pyrimidines, pubmed-meshheading:21258187-Respiration, Artificial
pubmed:year
2010
pubmed:articleTitle
[Chronic myeloid leukemia complicated with cerebellar hemorrhage and acute hydrocephalus successfully treated with imatinib and intensive supportive care].
pubmed:affiliation
Department of Internal Medicine, Matsuyama Red-Cross Hospital, Japan.
pubmed:publicationType
Journal Article, English Abstract, Case Reports