Linked Life Data

21258007

Source:http://linkedlifedata.com/resource/pubmed/id/21258007

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2011-3-18
pubmed:abstractText
CD4(+) natural killer T (NKT) cells, along with CD4(+)CD25(+) regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the adoptive transfer of highly purified (> 95%) CD4(+)NKT cells in a murine model of allogeneic hematopoietic cell transplantation (HCT). NKT cells follow a migration and proliferation pattern similar to that of conventional T cells (Tcons), migrating initially to secondary lymphoid organs followed by infiltration of graft-versus-host disease (GVHD) target tissues. NKT cells persist for more than 100 days and do not cause significant morbidity or mortality. Doses of NKT cells as low as 1.0 × 10(4) cells suppress GVHD caused by 5.0 × 10(5) Tcons in an interleukin-4 (IL-4)-dependent mechanism. Protective doses of NKT cells minimally affect Tcon proliferation, but cause significant reductions in interferon-? (IFN-?) and tumor necrosis factor-? (TNF-?) production by donor Tcons and in skin, spleen, and gastrointestinal pathology. In addition, NKT cells do not impact the graft-versus-tumor (GVT) effect of Tcons against B-cell lymphoma-1 (BCL-1) tumors. These studies elucidate the biologic function of donor-type CD4(+)NKT cells in suppressing GVHD in an allogeneic transplantation setting, demonstrating clinical potential in reducing GVHD in HCT.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3220-9
pubmed:meshHeading
pubmed-meshheading:21258007-Acute Disease, pubmed-meshheading:21258007-Adoptive Transfer, pubmed-meshheading:21258007-Animals, pubmed-meshheading:21258007-CD8-Positive T-Lymphocytes, pubmed-meshheading:21258007-Cell Movement, pubmed-meshheading:21258007-Cell Proliferation, pubmed-meshheading:21258007-Graft vs Host Disease, pubmed-meshheading:21258007-Inflammation Mediators, pubmed-meshheading:21258007-Interferon-gamma, pubmed-meshheading:21258007-Interleukin-2 Receptor alpha Subunit, pubmed-meshheading:21258007-Interleukin-4, pubmed-meshheading:21258007-Mice, pubmed-meshheading:21258007-Natural Killer T-Cells, pubmed-meshheading:21258007-Organ Specificity, pubmed-meshheading:21258007-T-Lymphocytes, pubmed-meshheading:21258007-T-Lymphocytes, Regulatory, pubmed-meshheading:21258007-Tumor Necrosis Factor-alpha
pubmed:year
2011
pubmed:articleTitle
Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism.
pubmed:affiliation
Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural