21255411

Source:http://linkedlifedata.com/resource/pubmed/id/21255411

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007131, umls-concept:C0007600, umls-concept:C0144576, umls-concept:C0332293, umls-concept:C0334227, umls-concept:C0441712, umls-concept:C1122962, umls-concept:C1521991, umls-concept:C1704675
pubmed:dateCreated	2011-8-11
pubmed:abstractText	Chemotherapy combined concurrently with TKIs produced a negative interaction and failed to improve survival when compared with chemotherapy or TKIs alone in the treatment of non-small cell lung cancer (NSCLC). The present study investigated the sequence-dependent interaction between paclitaxel and gefitinib and clarified the underlying mechanism.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101468937
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor alpha, http://linkedlifedata.com/resource/pubmed/chemical/gefitinib
pubmed:status	MEDLINE
pubmed:issn	1756-8722
pubmed:author	pubmed-author:AnShe-JuanSJ, pubmed-author:ChenZhi-HongZH, pubmed-author:ChengHuaH, pubmed-author:Jian-Su, pubmed-author:SongDongD, pubmed-author:WuYi-LongYL, pubmed-author:ZhangXu-ChaoXC, pubmed-author:ZhangYi-FangYF
pubmed:issnType	Electronic
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5
pubmed:meshHeading	pubmed-meshheading:21255411-Antineoplastic Agents, pubmed-meshheading:21255411-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:21255411-Cell Line, Tumor, pubmed-meshheading:21255411-Cell Proliferation, pubmed-meshheading:21255411-Drug Resistance, Neoplasm, pubmed-meshheading:21255411-Drug Synergism, pubmed-meshheading:21255411-Gene Expression Regulation, Neoplastic, pubmed-meshheading:21255411-Humans, pubmed-meshheading:21255411-Lung Neoplasms, pubmed-meshheading:21255411-Paclitaxel, pubmed-meshheading:21255411-Quinazolines, pubmed-meshheading:21255411-Receptor, Epidermal Growth Factor, pubmed-meshheading:21255411-Signal Transduction, pubmed-meshheading:21255411-Transforming Growth Factor alpha
pubmed:year	2011
pubmed:articleTitle	Molecular mechanism of the schedule-dependent synergistic interaction in EGFR-mutant non-small cell lung cancer cell lines treated with paclitaxel and gefitinib.

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